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. 2023 Oct 11;64(10):100440. doi: 10.1016/j.jlr.2023.100440

Fig. 5.

Fig. 5

Dietary fat supports neonatal survival via FAO and gluconeogenesis. A: Schematic of the rescue experiments for (B–M). From 6 h after birth, the Cidea+/−pups lactated by Cidea−/− females (low-fat milk, LFM) were orally administrated as four treatments: saline buffer as “vehicle”, fat emulsion supplementation as “Fat”, fat emulsion plus pent-4-enoate (FAO inhibitor) as “Fat + FAO i”, and fat emulsion plus 3-MPA (gluconeogenesis inhibitor) as “Fat + Gluconeo i”. B: The survival rates (n=15). C–E: Serum levels of TAG (C), NEFA (D), and β-hydroxybutyrate (E) (n = 4). F–I: Hepatic levels of TAG (F), FFA (G), β-hydroxybutyrate (H), and glucose (I) (n = 10). J: Protein level in livers by Western blotting (n = 2). K–M: The levels of blood glucose (K), brain glucose (I), and brain ATP (M) (n = 10). Data are presented as mean±s.e.m. Data were analyzed using a two-tailed Student’s t test. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. FAO, fatty acid oxidation; NEFA, nonesterified fatty acids; TAG, triacylglyceride.