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. 2023 Oct 1;8(40):36614–36627. doi: 10.1021/acsomega.3c02837

Table 1. Exosome Molecular Signature in Ovarian Cancer Progression.

Cancer development event Exosome molecule Function References
Uncontrolled cell growth miRNA-29a-3p Related to develop OC via down-regulation of FOXO3 (6)
Immune response reprogramming Arginase-1 Suppress T-cell activity and develop ovarian cancer (8)
Angiogenesis MALAT1 Promote angiogenesis-associated gene expression (7)
Metastasis TGFβ1 Ovarian tumor microenvironment-related fibroblast-derived exosome cargo associated TGFβ1 promotes EMT via the SMED signaling pathway (9)
Drug and therapeutic resistance miRNA223 Macrophage-derived exosome miRNA223 involved developing chemoresistance in ovarian cancer via the PTEN–PI3K/AKT signaling pathway (68)
Cancer stem cell development CD24 and EpCAM Both proteins are involved in ovarian cancer stem cell development (12)