Table 2.
Multivariate analysis of association of variations of the COW with covert vascular brain injury
| Outcomes | Anterior circulation |
Posterior circulation |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| symmetric | asymmetric |
complete | incomplete |
no FTP | FTP |
complete | incomplete |
|||||
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |||||
| Lacune | ||||||||||||
| Any lacune | 1 (Ref) | 1.205 (0.727–1.996) | 0.469 | 1 (Ref) | 1.246 (0.837–1.855) | 0.278 | 1 (Ref) | 1.221 (0.767–1.943) | 0.400 | 1 (Ref) | 0.774 (0.453–1.324) | 0.350 |
| Lacune – BG | 1 (Ref) | 1.322 (0.752–2.327) | 0.332 | 1 (Ref) | 1.243 (0.788–1.962) | 0.349 | 1 (Ref) | 1.015 (0.589–1.750) | 0.956 | 1 (Ref) | 0.778 (0.424–1.428) | 0.418 |
| Lacune-WM | 1 (Ref) | 0.891 (0.462–1.718) | 0.729 | 1 (Ref) | 1.282 (0.775–2.121) | 0.332 | 1 (Ref) | 1.878(1.069–3.298) | 0.028 | 1 (Ref) | 0.998 (0.503–1.978) | 0.995 |
| WMH | ||||||||||||
| Severe PVH | 1 (Ref) | 1.394 (0.886–2.193) | 0.151 | 1 (Ref) | 1.110(0.771–1.599) | 0.574 | 1 (Ref) | 1.348 (0.881–2.061) | 0.168 | 1 (Ref) | 1.744 (0.990–3.073) | 0.054 |
| Severe DWMH | 1 (Ref) | 1.291 (0.757–2.202) | 0.348 | 1 (Ref) | 0.862 (0.551–1.347) | 0.514 | 1 (Ref) | 1.739(1.064–2.842) | 0.027 | 1 (Ref) | 2.071 (1.004–4.270) | 0.049 |
| CMB | ||||||||||||
| Any CMB | 1 (Ref) | 0.718 (0.399–1.295) | 0.271 | 1 (Ref) | 1.542(1.012–2.348) | 0.044 | 1 (Ref) | 1.285 (0.781–2.116) | 0.324 | 1 (Ref) | 1.748 (0.904–3.381) | 0.097 |
| Deep or infratentorial CMB | 1 (Ref) | 0.393 (0.150–1.027) | 0.057 | 1 (Ref) | 1.567(0.900–2.730) | 0.113 | 1 (Ref) | 1.279 (0.658–2.485) | 0.468 | 1 (Ref) | 1.406 (0.624–3.166) | 0.411 |
| Strictly lobar CMB | 1 (Ref) | 1.180 (0.571–2.440) | 0.655 | 1 (Ref) | 1.499 (0.826–2.721) | 0.183 | 1 (Ref) | 1.271 (0.635–2.546) | 0.498 | 1 (Ref) | 2.284 (0.784–6.652) | 0.130 |
| EPVS | ||||||||||||
| Severe EPVS – BG | 1 (Ref) | 0.958(0.577–1.593) | 0.870 | 1 (Ref) | 0.952 (0.648–1.399) | 0.802 | 1 (Ref) | 0.734 (0.449–1.200) | 0.218 | 1 (Ref) | 1.750(0.946–3.240) | 0.075 |
| Severe EPVS – WM | 1 (Ref) | 1.040 (0.639–1.694) | 0.873 | 1 (Ref) | 0.682 (0.468–0.996) | 0.048 | 1 (Ref) | 0.562 (0.346–0.915) | 0.020 | 1 (Ref) | 0.716 (0.445–1.153) | 0.169 |
Models are adjusted for age and sex. OR, odds ratio; Cl, confidence interval; Ref, reference; FTP, fetal-type posterior cerebral artery; WMH, white matter hyperintensity; PVH, periventricular hyperintensity; DWMH, deep white matter hyperintensity; CMB, cerebral microbleed; EPVS, enlarged perivascular space; BG, basal ganglia; WM, white matter.