Figure 1.

GER abated CFA-induced paw inflammation. IA was induced by injecting 100 μL of CFA in the right hind paw of the rats. After 7 days, treatments were given with the mentioned doses of MTX and GER. Paw volume was measured with a digital plethysmometer to check the edema at the mentioned intervals of time. GER at 25 and 50 mg/kg reduced paw edema, which was comparable to the MTX-treated group. # ≤ 0.001 (two-way ANOVA followed by a Bonferroni multiple comparison test); significant acronyms (#) represent the comparison of treatment groups with the disease group (CFA); n = 7.