Figure 3.

Hematological and biochemical analysis revealed protective effects of GER against CFA-induced IA damage. IA was induced by injecting 100 μL of CFA, and after a week of CFA administration, rats were treated with the mentioned doses of MTX or GER. Treatments were given every other day until day 35, and later, animals were sacrificed. Biochemical and hematological parameters were analyzed using an automatic hematology and biochemical analyzer machine. GER successfully restored (A) RBC, (B) Hb, (C) ESR, (D) WBC, (E) PLT, and (F) CRP levels. GER (100 mg/kg) induced (G) AST, (H) ALT, and (I) ALP, displaying its hepatotoxic potential at higher doses. # ≤ 0.001 (one-way ANOVA followed by the Tukey’s multiple comparison test); significant acronyms (#) represent the comparison of treatment groups with the disease group (CFA); n = 7.