Fig. 7.

Schematic summation of the proposed pathway of activation of the luminal NKCC1 in the CP. The pro-inflammatory cytokines TNFα and IL-1β as well as LPS activate receptors in the luminal membrane of the CP that faces the CSF. This initiates the activation of the NF-κB pathway. The receptor for IL-6 is present in the basolateral membrane and activates the JAK/STAT pathway. In this study, IL-6 leads to increased abundance of pNKCC1 in the luminal membrane, whereas the activation of the luminal receptors has little or no effect on either Ncbe and NKCC1. Please see text for further details