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. 2023 Oct 12;20:71. doi: 10.1186/s12987-023-00474-9

Table 2.

Values are presented as mean ± standard error; n.s.:no statistical significance, and *p < 0.05, n = 5

TEER values (Ω*cm2)
TNFα
Treatment Control 1 pg/mL 1 ng/mL 100 ng/mL
24 h Start 138 ± 8 149 ± 8 154 ± 11 157 ± 8
End 122 ± 8 n.s. 140 ± 11 n.s. 132 ± 6 n.s. 132 ± 7*
48 h Start 217 ± 12 195 ± 14 212 ± 20 230 ± 22
End 233 ± 22 n.s. 218 ± 3 n.s. 229 ± 37 n.s. 206 ± 10 n.s.
IL-1β
Treatment Control 1 pg/mL 1 ng/mL 100 ng/mL
24 h Start 143 ± 13 140 ± 14 144 ± 12 165 ± 13
End 145 ± 19 n.s. 157 ± 18 n.s. 131 ± 19 n.s. 132 ± 15*
48 h Start 143 ± 9 136 ± 9 135 ± 7 150 ± 7
End 142 ± 19 n.s. 136 ± 18 n.s. 145 ± 13 n.s. 165 ± 18 n.s.
IL-6
Treatment Control 1 pg/ml 1 ng/ml 100 ng/ml
24 h Start 132 ± 4 127 ± 9 137 ± 4 143 ± 7
End 141 ± 7 n.s. 138 ± 5 n.s. 139 ± 12 n.s. 147 ± 6 n.s.
48 h Start 174 ± 18 195 ± 19 164 ± 15 178 ± 29
End 190 ± 15 n.s. 204 ± 16 n.s. 193 ± 12 n.s. 190 ± 27 n.s.
100 ng/mL prolonged treatment
Treatment Control TNFα IL-1β IL-6
72 h Start 170 ± 30 177 ± 54 152 ± 30 221 ± 20
End 147 ± 27 n.s. 148 ± 29 n.s. 159 ± 21 n.s. 166 ± 14*