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. 2023 Oct 12;23:971. doi: 10.1186/s12885-023-11410-3

Table 2.

Correlation of clinicopathological and demographic parameters of CRC patients with cholinergic markers

Parameters No. of cases Percentage (%) α7nAChR expression
Low High
P values
Total 91 100 49 (53.8%) 42 (46.2%)

Gender

Male

Female

51

40

56.0

44.0

30 (33.0%)

19 (20.9%)

21 (23.1%)

21 (23.1%)

0.194

Age

<65

>65

41

50

45.1

54.9

24 (26.4%)

25 (27.5%)

17 (18.7%)

25 (27.5%)

0.274

Stage

I + II

III + IV

14

33

15.4

36.3

30 (33.0%)

19 (20.9%)

19 (20.9%)

23 (25.3%)

0.094
Parameters No. of cases Percentage (%)

M3R expression

Low High

P values
Total 91 100 58 (63.7%) 33 (36.3%)

Gender

Male

Female

51

40

56.0

44.0

31 (34.1%)

27 (29.7%)

20 (22.0%)

13 (14.3%)

0.508

Age

<65

>65

41

50

45.1

54.9

22 (24.2%)

36 (39.6%)

19 (20.9%)

14 (15.4%)

0.070

Stage

I + II

III + IV

49

42

53.8

46.2

38 (41.8%)

11 (12.1%)

11 (12.1%)

31 (34.1%)

0.017
Parameters No. of cases Percentage (%)

ChAT expression

Low High

P values
Total 91 100 32 (35.2%) 59 (64.8%)

Gender

Male

Female

51

40

56.0

44.0

30 (33.0%)

19 (20.9%)

21 (23.1%)

21 (23.1%)

0.194

Age

<65

>65

41

50

45.1

54.9

24 (26.4%)

25 (27.5%)

17 (18.7%)

25 (27.5%)

0.274

Stage

I + II

III + IV

49

42

53.8

46.0

30 (33.0%)

14 (15.4%)

19 (20.9%)

28 (30.6%)

0.049

P values are based on the frequency of cholinergic markers within each parameter