Table 3. Voxel-based FC analysis of the regions with decreased GMV in patients (voxel-level uncorrected p < 0.0001, non-stationary cluster-level FWE correction with p < 0.05).
| Cluster | Sub-cluster | FC regions | MNI coordinates | Peak T value | Cluster size (voxels) | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| TPOsup_R/IFGorb_R | TPOsup_R | Heschl_L/INS_L | −42 | −15 | 6 | −5.44 | 17 |
| IFGorb _R | MCC_R/SMA_R/MCC_L | 0 | −6 | 45 | −4.94 | 30 | |
| INS_L | −39 | −15 | 6 | −5.42 | 13 | ||
| SFGorb_R/SFG_R/ | SFGorb_R | MCC_R/precuneus_R | 6 | −39 | 39 | −5.09 | 19 |
| MFG_R/PFCventmed_R | SFG_R | None | |||||
| MFG_R | MCC_R/precuneus_R | 6 | −45 | 48 | −5.30 | 49 | |
| PFCventmed_R | MCC_R/precuneus_R | 6 | −39 | 39 | −5.78 | 34 | |
| INS_L/IFGorb _L | INS_L | R_PUT | 21 | 15 | −3 | −5.06 | 14 |
| IFGorb_L | None | ||||||
Notes.
- MNI
- Montreal Neurological Institute
- ROI
- region of interest
- L
- left
- R
- right
- TPOsup
- the pars orbitalis in the inferior frontal gyrus
- IFGorb
- the pars orbitalis in the inferior frontal gyrus
- INS
- insular
- MCC
- middle cingulate
- SMA
- supplementary motor areas
- SFGorb
- pars orbitalis in superior frontal gyrus
- SFG
- superior frontal gyrus
- MFG
- middle frontal gyrus
- PFCventmed
- medial orbital in the superior frontal gyrus
- PUT
- Putamen