Table 3.

Relationship of SII, ALBI and SII+ALBI grade with clinicopathological characteristics of intrahepatic cholangiocarcinoma (ICC) after radical resection in the training set.

	SII		X2	p-value	ALBI		X2	p-value	SII+ALBI Grade			X2	p value
	Low group	High group			Low group	High group			Grade A	Grade B	Grade C
Sex			1.768	0.184			0.012	0.912				3.294	0.193
Male	60	80			97	43			44	69	27
Female	41	77			81	37			26	70	22
Age			0.911	0.340			0.002	0.964				7.010	0.030
≤65	61	104			114	51			38	99	28
>65	40	53			64	29			32	40	21
Obstructive jaundice			0.017	0.897			18.259	<0.001				10.157	0.006
No	83	130			159	54			62	118	33
Yes	18	27			19	26			8	21	16
HBV infection			6.834	0.009			3.805	0.051				11.015	0.004
No	56	112			109	59			35	95	38
Yes	45	45			69	21			35	44	11
AFP (ng/ml)			0.947	0.331			1.351	0.245				2.280	0.320
<20	83	136			148	71			56	119	44
≥20	18	21			30	9			14	20	5
CEA (ng/ml)			9.779	0.002			0.269	0.604				7.978	0.019
<5	76	88			115	49			54	83	27
≥5	25	69			63	31			16	56	22
CA19-9 (U/ml)			5.880	0.015			7.205	0.007				16.720	<0.001
<37	48	51			78	21			41	44	14
≥37	53	106			100	59			29	95	35
SII							0.008	0.930				156.891	<0.001
Low group					70	31			70	31	0
High group					108	49			0	108	49
ALBI			0.008	0.930								145.410	<0.001
Low group	70	108							70	108	0
High group	31	49							0	31	49
SII+ALBI grade			156.891	<0.001			145.410	<0.001
Grade A	70	0			70	0
Grade B	31	108			108	31
Grade C	0	49			0	49
Child–Pugh grade			0.171	0.679			54.684	<0.001				31.612	<0.001
Grade A	91	142			177	56			69	130	34
Grade B	10	15			1	24			1	9	15
Tumor Number			2.840	0.092			0.004	0.947				2.383	0.304
=1	87	122			144	65			61	109	39
>1	14	35			34	15			9	30	10
Tumor Size(cm)			19.244	<0.001			2.223	0136				7.382	0.025
≤5	58	47			67	38			38	49	18
>5	43	110			111	42			32	90	31
Tumor differentiation			1.062	0.588			5.498	0.064				6.736	0.151
Well	13	14			23	4			10	17	11
Moderate	73	120			133	60			49	108	36
Poor	15	23			22	16			11	14	2
Perineural invasion			9.145	0.002			10.043	0.002				19.220	<0.001
No	67	74			109	32			52	72	17
Yes	34	83			69	48			18	67	32
Microvascular invasion			0.500	0.480			1.296	0.255				1.679	0.432
No	58	84			102	40			42	76	24
Yes	42	73			75	40			27	63	25
AJCC 8th edition T stage			7.729	0.021			3.851	0.146				3.737	0.443
T1a/T1b	55	62			80	37			38	59	20
T2	35	60			61	34			22	52	21
T3/T4	11	35			37	9			10	28	8
AJCC 8th edition N stage			2.403	0.121			0.671	0.413				0.398	0.819
N0	79	109			127	61			53	100	35
N1	22	48			51	19			17	39	14
AJCC 8th edition M stage			0.043	0.836			1.804	0.179				1.244	0.537
M0	100	155			177	78			70	137	48
M1	1	2			1	2			0	2	1