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. Author manuscript; available in PMC: 2023 Oct 12.
Published in final edited form as: Nat Methods. 2023 Mar 27;20(5):682–685. doi: 10.1038/s41592-023-01819-w

Extended Data Fig. 1 |. Synthesis of CNV-Y-DAMGO (4).

Extended Data Fig. 1 |

The N-terminal amine in DAMGO (3) was Boc-protected prior to phenol alkylation with 6. Global deprotection with TFA produced CNV-Y-DAMGO (4) in good overall yield