TABLE 2.
Measured pharmacokinetic variables
| Variable | Valuea |
|---|---|
| Initial clinician-determined dose (mg/kg) | 1.6 (1.4–1.9) |
| Initial dosing interval (h) | 12 (12–12) |
| First measured Cmax (μg/ml) | 5.3 (3.9–6.3) |
| First measured Cmin (μg/ml) | 0.6 (0.3–1.1) |
| First measured Cmax/MIC | 3.6 (1.4–6.2) |
| Aminoglycoside clearance (ml/min/1.73 m2) | 71.5 (50.4–91.3) |
| Half-life (h) | 3.5 (2.6–5.0) |
| Volume of distribution (liters) | 20.2 (16.3–27.8) |
| Volume of distribution (liter/kg) | 0.32 (0.27–0.38) |
| Adjusted dose (mg/kg) | 2.4 (1.9–2.8) |
| Adjusted dosing interval (h) | 12 (12–18) |
| Second measured Cmax (μg/ml) | 6.7 (5.2–7.6) |
| Second measured Cmin (μg/ml) | 0.8 (0.5–1.1) |
a
Data presented as median (25th to 75th percentile).