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. 2023 Sep 28;14:1276014. doi: 10.3389/fimmu.2023.1276014

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Copyright © 2023 Ono, Tanaka, Myouzen, Iwasaki, Ueda, Oda, Yamamoto, Kochi and Baba

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell anergy is disrupted in Fcrl5 Tg mice. (A) Anti-HEL antibody production in serum isolated from MD4 Tg (n=12), MD4/Fcrl5 Tg (n=12), MD4/ML5 Tg (n=21), and MD4/ML5/Fcrl5 Tg (n=25) mice, assayed by ELISA. Data are pooled from six independent experiments. (B) Top, representative flow cytometry plots and absolute numbers of splenic CD19⁺, CD23^–CD21^lo (CD19⁺CD93^–CD23^–CD21^lo), FO B (CD19⁺CD93^–CD23⁺CD21^lo), and MZ B (CD19⁺CD93^–CD23^–CD21^hi) cells from MD4 Tg (n=12), MD4/Fcrl5 Tg (n=12), MD4/ML5 Tg (n=35), and MD4/ML5/Fcrl5 Tg (n=40) mice. Data are pooled from eight independent experiments. Statistical data are shown as mean values with s.d., and data were analyzed by Kruskal-Wallis with Dunn’s multiple comparisons test (A) or one-way ANOVA with Tukey’s multiple comparisons test (B). *P<0.05, **P<0.01, ****P<0.0001.