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. 2023 Oct 2;19(10):e1011707. doi: 10.1371/journal.ppat.1011707

Fig 8. Summary.

Fig 8

A) Diagram summarizing the effects of IMC43 depletion. Depletion of IMC43 causes gross morphological defects such as swelling, cytoskeletal instability, asynchronous division, excess budding & nuclear division, and loss of overall lytic ability. Assembly of the basal complex and apical cap remain unaffected. B) Diagram summarizing the relationship between IMC43 and its binding partners IMC32 and IMC44. The newly identified Localization domain (LOC) and Essential Interaction Domain (EID) of IMC43 are shown. Grey boxes indicate interactions between the Essential Interaction Domain of IMC43 and IMC32/IMC44. Boxed panels include a diagram showing how depletion of IMC43 affects the localization of IMC32 and IMC44 throughout bud initiation (1), early/mid-budding (2), and late budding (3).