Mosquitoes were allowed to feed on ZIKV-BC-infected mice and were examined at days 4, 7, and 14 post-feeding to determine infection, dissemination, and transmission efficiencies. Infection efficiency corresponds to the proportion of mosquitoes with virus-infected bodies among the tested ones. Dissemination efficiency corresponds to the proportion of mosquitoes with virus-infected legs, and transmission efficiency corresponds to the proportion of mosquitoes with infectious saliva. *significant reduction in infection rates (Fisher’s Exact test *p < 0.05, **p < 0.01, ***p < 0.001, ****p<0.0001) (A). 4 days post-feeding (Biological replicate number 1, n = 30; Biological replicate number 2, n = 30; Biological replicate 3, n = 30) (B). 7 days post feeding (n = 30; Biological replicate number 2, n = 30; Biological replicate 3, n = 30) (C). 14 days post feeding (n = 30; Biological replicate number 2, n = No Data; Biological replicate 3, n = 30).