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. 2023 Oct 2;17(10):e0011674. doi: 10.1371/journal.pntd.0011674

Fig 4. Transcriptional changes in COL.wMel relative to COL.tet following a ZIKV-infected bloodmeal.

Fig 4

(A) Volcano plots showing differentially expressed transcripts in midgut and carcass tissues at 4 and 7 dpf after a ZIKV-infected bloodmeal, highlighting Aedes aegypti predicted innate immune genes (highlighted in magenta). Significant changes are transcripts with |log2FoldChange| >1 (vertical red and blue dashed lines) and -log10(padj) > 0.05 (horizontal yellow dashed line). Aedes aegpyti predicted innate immune genes are highlighted in magenta. (B) Heatmap of mosquito innate immune gene expression patterns in ZIKV-exposed COL.wMel and COL.tet mosquitos. The list of predicted innate immune genes was chosen from transcripts differentially regulated in COL.wMel carcass tissue 4dpf. (C) Transcripts with constitutively increased abundance (red) and decreased abundance (blue) between both collection time points. Transcripts with a difference in log2FoldChange > 2.5 are labeled and that are characterized in VectorBase are labeled. Alpha-actinin (AAEL007306). No genes went from being significantly increased to significantly decreased or vice versa between 4 dpf and 7dpf.