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. 2023 Oct 12;18(10):e0292835. doi: 10.1371/journal.pone.0292835

Table 1. Hemoglobin levels as covariates of absolute and relative maximal oxygen uptake (V˙O2max) derived from observational analyses.

Absolute V˙O2max (L·min-1)
Coefficient [95% CI] P value R 2 τ 2 n
Hemoglobin mass
    All data 0.005 [0.003, 0.007] <0.0001 0.49 0.34 42
    Males 0.006 [0.004, 0.009] <0.0001 0.66 0.41 23
    Females 0.011 [0.008, 0.015] <0.0001 0.92 0.31 8
Hemoglobin concentration
    All data 0.404 [0.298, 0.510] <0.0001 0.29 0.77 199
    Males 0.148 [0.022, 0.274] 0.022 0.15 0.51 141
    Females 0.226 [0.060, 0.393] 0.008 0.22 0.31 41
Relative V˙O2max (mL·min -1 ·kg -1 )
Hemoglobin mass
    All data 0.058 [0.039, 0.077] <0.0001 0.55 130.27 58
    Males 0.054 [0.024, 0.084] <0.0001 0.19 67.75 37
    Females 0.137 [0.016, 0.258] 0.027 0.34 28.44 8
Hemoglobin concentration
    All data 4.649 [2.650, 6.648] <0.0001 0.10 121.87 284
    Males 0.882 [-1.120, 2.884] 0.388 0.02 83.77 175
    Females 5.999 [3.249, 8.728] <0.0001 0.45 67.59 63

Data depict results of independent meta-regressions in determination of hemoglobin levels (hemoglobin mass and hemoglobin concentration) as covariates of absolute V˙O2max and relative V˙O2max. Data were pooled from each study to provide one single data point for ‘All data’ derived coefficients (n denotes the number of studies). Additional independent analyses were performed for subgroups of data reporting males only and females (n denotes the number of subgroups). Abbreviations: CI, confidence interval.