TABLE 2.
Pharmacokinetics of ITR: SOS versus F12a
| Form of ITR | Cmax (ng/ml) | Tmax (h) | t1/2 (h) | AUC0–96 (ng · h/ml) | AUC0–∞ (ng · h/ml) |
|---|---|---|---|---|---|
| SOS | 306.4 (101.5) | 5.0 | 22.1 | 5,550.2 (132.7) | 5,838.0 (131.4) |
| F12 | 301.9 | 4.9 | 22.9 | 4,183.4 | 4,441.3 |
| 90% CIb | 91.2–111.7 | 97.3–106.8 | 91.4–101.5 | 120.4–144.9 | 119.2–143.7 |
a
Reference is F12. All pharmacokinetic values except bioavailability are least-squares means. Numbers in parentheses are bioavailabilities (indicated as percentages) of SOS relative to F12.
b
For explanation of 90% CI, see Table 1, footnote b.