TABLE 3.
Pharmacokinetics of OH-ITR: SOS versus F05a
| Form of OH-ITR | Cmax (ng/ml) | Tmax (h) | t1/2 (h) | AUC0–96 (ng · h/ml) | AUC0–∞ (ng · h/ml) |
|---|---|---|---|---|---|
| SOS | 527.0 (105.2) | 5.7 | 10.7 | 14,889.3 (137.3) | 15,025.5 (137.4) |
| F05 | 501.0 | 5.5 | 10.3 | 10,847.8 | 10,937.8 |
| 90% CIb | 97.1–113.3 | 94.3–113.0 | 97.0–110.5 | 124.9–149.6 | 124.9–149.9 |
a
Reference is F05. All pharmacokinetic values except bioavailability are least-squares means. Numbers in parentheses are bioavailabilities (expressed as percentages) of SOS relative to F05.
b
For explanation of 90% CI, see Table 1, footnote b.