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. 2023 Aug 24;51(18):10011–10025. doi: 10.1093/nar/gkad674

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — The chromatin interaction landscape of LEDGF. (A) Spatial considerations for LEDGF binding to chromatin. Approximate dimensions of nucleosomes and LEDGF molecule in extended or compacted form. (B) Possible distribution for LEDGF domains across a mononucleosome or nucleosomal array. (C) Hypothetical role of the central region of LEDGF in the positioning of elongation factors near RNA polymerase II at actively transcribed gene bodies marked by a H3K36 methylation. The PWWP domain is highlighted in green and the IBD in pink.