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. 2023 Sep 4;14(5):2003–2015. doi: 10.1002/jcsm.13276

Figure 1.

Figure 1

Experimental design. After a 1‐week acclimatization period (D‐14), 70 11‐week‐old female fisher rats received tumour injection (C + C rats). One week later (D‐7), all the animals (n = 78) received the normal‐protein diet. Then, after 13 days of tumour growth (D‐2), the rats received either the normal‐protein diet (NP16%, n = 14) or a low‐protein diet with 8% protein (LP8%, n = 14), a low‐protein diet with 12% protein (LP12%, n = 14), a high‐protein diet with 24% protein (HP24%, n = 14) or a high‐protein diet with 32% protein (HP32%, n = 14). Two days later, the first chemotherapy cycle was initiated: irinotecan (CPT‐11; 50 mg/kg; dark grey arrow) at D0 and 5‐fluorouracil (5‐FU; 50 mg/kg; light grey arrow) at D1. One week later, the rats received the second cycle of chemotherapy (CPT‐11 at D7 and 5‐FU at D8). The rats were sacrificed at D9 for analysis.