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. 2023 Aug 8;14(5):2204–2215. doi: 10.1002/jcsm.13303

Figure 2.

Figure 2

Muscle histochemistry in SOD1KO muscle. (A) Gastrocnemius muscle of an untreated SOD1KO mouse showing muscle fibre size variability, atrophic angular FTG fibres (red arrows) and oxidative (yellow star) and glycolytic (red star) fibre type groupings as neurogenic change with SDH stain. (B) Subsarcolemmal mitochondria accumulation (arrows) depicted as ragged blue (with SDH)/ragged brown (with COX) fibres and COX deficient fibres (star) in muscles from untreated SOD1KO mouse. (C) Bar graph shows increase in fibre diameter in gastrocnemius muscle (n = 7 untreated, n = 11 treated, P = 0.01). (D) Bar graph shows increase in fibre diameter in tibialis anterior muscle (n = 6 untreated, n = 6 treated, P = 0.021). (E, F) Representative images from superficial and deep regions of an SDH‐stained cross section from tibialis anterior muscle in an NT‐3 treated SOD1KO mouse. Scale bar is 30 μm for all images. Error bars are ± SEM, two‐way ANOVA, Bonferroni's multiple comparisons test.