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. 2023 Jul 12;14(5):2152–2167. doi: 10.1002/jcsm.13292

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© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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An analysis reveals common mechanisms regulating bovine and human IMF and IMC accumulation. (A) Heatmaps show the expression of select adipogenic and fibrogenic genes in bovine, human, monkey, and uninjured WT mouse FAP clusters. (B, C) The differential expression of select adipogenic and fibrogenic genes in human SkM among young, old, and old with metabolic syndrome individuals (B). The correlation between the expression of select genes and the expression of CFD in human SkM across all groups (C). (D) The differential expression of select adipogenic and fibrogenic genes in human SkM between DMD patients and healthy controls aged 1 year or less. (E) The differential expression of select adipogenic and fibrogenic genes in SkM between DMD patients and healthy controls aged 2 to 8 years (left) and expression correlation between these genes (right). (F) A schematic diagram of the proposed mechanism regulating IMF and IMC accumulation in cattle and humans. *P < 0.05; **P < 0.01; ***P < 0.001.