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. 2023 Oct 12;14:6370. doi: 10.1038/s41467-023-42170-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Low PA cellular levels cause PHF2-mediated SREBP1c degradation (left panel). PA-enriched conditions enhance ZDHHC23-dependent PHF2 palmitoylation, resulting in the proteasomal degradation of PHF2. Following PHF2 degradation, SREBP1c becomes stable and induces PA levels in HCC cells (right panel). Finally, the vicious cycle of PA/PHF2/SREBP1c results in a poor HCC prognosis.