Table 1.
Regional lead variants for the eight loci significantly associated with Raynaud’s phenomenon
| Tier | SNP | Chr | Position | Alleles | MAF | OR (95% CI) | P-value | Closest genea |
|---|---|---|---|---|---|---|---|---|
| 1 | rs7090046 | 10 | 112860930 | A/G | 0.31 | 1.26 (1.20, 1.31) | 9.58 × 10−27 | ADRA2A |
| 1 | rs12653958 | 5 | 4032849 | A/G | 0.30 | 1.16 (1.12, 1.22) | 4.76 × 10−13 | IRX1 |
| 2 | rs3094013 | 6 | 31434366 | G/A | 0.14 | 1.17 (1.11, 1.24) | 9.73 × 10−9 | MICB |
Tier = categorization whether genetic loci met a stringent Bonferroni threshold for significance (tier 1; p < 1.0 × 10−9) or the standard genome-wide significance threshold (tier 2; p < 5.0 × 10−8). N = 444,441, 5147 cases, and 439,294 controls. Alleles are given as effect allele/non-effect allele.
Chr chromosome, MAF minor allele frequency, OR odds ratio from logistic regression models.
aProtein coding gene in italics.