Table 3.
Performance characteristics of the TIMI, GRACE, and HEART risk scales.
| Accuracy(95%CI) | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | False Negative Rate | False positive rate | |
|---|---|---|---|---|---|---|---|
| TIMI score | |||||||
| TOTAL > = 1 | 41.96 (36.46–47.6) | 91.49 (79.62–97.63) | 33.33 (27.74–39.3) | 19.28 (14.32–25.08) | 95.74 (89.46–98.83) | 8.51 (2.37–20.38) | 66.67 (60.7–72.26) |
| TOTAL > = 2 | 61.83 (56.23–67.2) | 78.72 (64.34–89.3) | 58.89 (52.76–64.82) | 25 (18.25–32.78) | 94.08 (89.39–97.13) | 21.28 (10.7–35.66) | 41.11 (35.18–47.24) |
| TOTAL > = 3 | 75.71 (70.6–80.33) | 44.68 (30.17–59.88) | 81.11 (75.92–85.6) | 29.17 (19.05–41.07) | 89.39 (84.84–92.95) | 55.32 (40.12–69.83) | 18.89 (14.4–24.08) |
| TOTAL > = 5 | 83.28 (78.71–87.22) | 12.77 (4.83–25.74) | 95.56 (92.37–97.68) | 33.33 (13.34–59.01) | 86.29 (81.86–89.98) | 87.23 (74.26–95.17) | 4.44 (2.32–7.63) |
| GRACE score | |||||||
| TOTAL > = 50 | 20.82 (16.48–25.71) | 97.87 (88.71–99.95) | 7.41 (4.58–11.21) | 15.54 (11.61–20.18) | 95.24 (76.18–99.88) | 2.13 (0.05–11.29) | 92.59 (88.79–95.42) |
| TOTAL > = 75 | 43.53 (38–49.19) | 78.72 (64.34–89.3) | 37.41 (31.62–43.48) | 17.96 (12.97–23.9) | 90.99 (84.06–95.59) | 21.28 (10.7–35.66) | 62.59 (56.52–68.38) |
| TOTAL > = 100 | 64.04(58.49–69.33) | 57.45 (42.18–71.74) | 65.19 (59.17–70.86) | 22.31 (15.25–30.78) | 89.8 (84.68–93.65) | 42.55 (28.26–57.82) | 34.81 (29.14–40.83) |
| TOTAL > = 109 | 68.45(63.03–73.53) | 46.81 (32.11–61.92) | 72.22 (66.47–77.48) | 22.68 (14.79–32.3) | 88.64 (83.68–92.51) | 53.19 (38.08–67.89) | 27.78 (22.52–33.53) |
| TOTAL > = 141 | 81.7 (77–85.8) | 25.53 (13.94–40.35) | 91.48 (87.49–94.52) | 34.29 (19.13–52.21) | 87.59 (83.16–91.2) | 74.47 (59.65–86.06) | 8.52 (5.48–12.51) |
| HEART score | |||||||
| TOTAL > = 1 | 18.3 (14.2–23) | 100 (92.45–100) | 4.07 (2.05–7.17) | 15.36 (11.51–19.9) | 100 (71.51–100) | 0 (0–7.55) | 95.93 (92.83–97.95) |
| TOTAL > = 2 | 26.81 (22.02–32.05) | 100 (92.45–100) | 14.07 (10.16–18.8) | 16.85 (12.65–21.76) | 100 (90.75–100) | 0 (0–7.55) | 85.93 (81.2–89.84) |
| TOTAL > = 3 | 37.85 (32.49–43.45) | 97.87 (88.71–99.95) | 27.41 (22.18–33.14) | 19.01 (14.27–24.53) | 98.67 (92.79–99.97) | 2.13 (0.05–11.29) | 72.59 (66.86–77.82) |
| TOTAL > = 4 | 54.26 (48.6–59.84) | 87.23 (74.26–95.17) | 48.52 (42.42–54.65) | 22.78 (16.87–29.61) | 95.62 (90.71–98.38) | 12.77 (4.83–25.74) | 51.48 (45.35–57.58) |
| TOTAL > = 7 | 81.7 (77–85.8) | 29.79 (17.34–44.89) | 90.74 (86.64–93.92) | 35.9 (21.2–52.82) | 88.13 (83.73–91.69) | 70.21 (55.11–82.66) | 9.26 (6.08–13.36) |
CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; TIMI score: low risk determined by score = < 2, moderate risk determined by score = < 4, and high risk determined by score > = 5; GRACE score: low risk determined by score < = 108, moderate risk determined by score > = 109, and high risk determined by score > = 141; HEART score: low risk determined by score = < 3, moderate risk determined by score > = 4, and high risk determined by score > = 7.