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. 2023 Oct 12;14(10):674. doi: 10.1038/s41419-023-06213-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative immunohistology stainings against endogenous p63 (clone 4A4) in matched non-transformed and human NSCLC-SCC. Scale bar = 1 mm or 2 mm, respectively. B Immunohistology analysis of non-transformed and matched NSCLC-SCC tumors exposed to HA-tagged control-DARPin and DARPins A2 and F11 as indicated, followed by HA-epitope specific antibodies. The tumor area is highlighted by dashed lines. Scale bar = 50 µm. C Quantitative analysis of IHC intensity in human SCC using DARPins F11 and A2, compared to control DARPin in mirco-array sections. The analysis was conducted with the image analysis software QuPath (0.4.2). D Parallel coordinate plots of total positive cells for DARPin F11 and control DARPin. Every connected dot represents a tumor sample of one patient with positive immunohistology signal in cells [%] of DARPin F11 or control DARPin. Mann-Whitney Test p > 0.001. E Pearson correlation between positive immunohistology signals of DARPin F11 versus DARPin A2 in human SCC tumor cores of a NSCLC tissue micro array (R = Pearson correlation coefficient, p = two tailed t test).