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. 2023 Sep 29;11:1219218. doi: 10.3389/fcell.2023.1219218

FIGURE 5.

FIGURE 5

ASC spheroids from sRC were more responsive to LPS stimulus compared with sSAT and dSAT. Secretion of IL-6 (A), IL-8 (B), IL-10 (C), IL12p70 (D), MCP-1 (E), VEGF (F) CCL5 (G), CCL10 (H), and CCL11 (I) of induced spheroids for the adipogenic pathway under LPS stimulus from sSAT, sRC, and dSAT. One independent analysis was evaluated in quadruplicate from 162 spheroids of each sample obtained from four independent experiments. Data are expressed as mean ± SD. The ANOVA test evaluated the difference between ASC spheroids from sSATl, sRC, and dSAT within each group: induced spheroids for the adipogenic pathway under LPS stimulus. Dashed lines indicate post-test analyses under both conditions. Solid lines indicate t-test analyses, which were performed to verify the statistical difference between induced spheroids for the adipogenic pathway under LPS stimulus from sSAT, sRC, and dSAT. Asterisks indicate p values obtained in the post-test and in the t-test (*p < 0.05; **p < 0.001; ***p < 0.001; **** p < 0.0001). SAT, subcutaneous adipose tissue; LPS, lipopolysaccharide; ASC, stem/stromal cells from adipose tissue; IL, interleukin; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; IL-12p70, interleukin-12; IL-15, interleukin-15; IFN-γ, interferon-γ; MCP-1, monocyte chemoattractant protein-1; bFGF, basic fibroblast growth factor; VEGF, vascular endothelial growth factor; GM-CSF, granulocyte-macrophage colonyQ18 stimulating factor; G-CSF, granulocyte colony stimulating factor; PDGF-BB, platelet-derived growth factor; CCL, CC chemokine ligand.