Table 4.

Commercial NGS testing companies and clinical tests available in the United States.

Company	Genodermatoses		Melanoma susceptibility
	EB	Ichthyosis
GeneDx	28 CD151, CDSN, CHST8, COL17A1, COL7A1, CSTA, DSG1, DSP, DST, EXPH5, FERMT1, FLG2, ITGA3, ITGA6, ITGB4, JUP, KLHL24, KRT1, KRT10, KRT14, KRT5, LAMA3, LAMB3, LAMC2, PKP1, PLEC, SERPINB8, TGM5	49 ABCA12, ABHD5, ALDH3A2, ALOX12B, ALOXE3, AP1S1, ARSL (ARSE), CASP14, CDSN, CERS3, CHST8, CLDN1, CSTA, CYP4F22, EBP, ELOVL4, FLG, FLG2, GJB2, GJB3, GJB4, GJB6, KDSR, KRT1, KRT10, KRT2, KRT9, LIPN, LOR, MBTPS2, NIPAL4, NSDHL, PEX7, PHGDH, PHYH, PNPLA1, POMP, PSAT1, SDR9C7, SERPINB8, SLC27A4, SNAP29, SPINK5, ST14, STS, TGM1, TGM5, VPS33B, ZMPSTE24	9 BAP1, BRCA2, CDK4, CDKN2A, MITF, POT1, PTEN, RB1, TP53
Fulgent	13 CD151, COL17A1, COL7A1, DSP, ITGA3, ITGB4, KRT14, KRT5, LAMA3, LAMB3, LAMC2, MMP1, PLEC	44 ABCA12, ABHD5, ALDH3A2, ALOX12B, ALOXE3, AP1S1, ARSE, CASP14, CERS3, CLDN1, CRYL1, CYP4F22, EBP, ELOVL4, ERCC2, ERCC3, FLG, GJA1, GJB2, GJB3, GJB4, GJB6, GTF2H5, KRT1, KRT10, KRT2, KRT9, LIPN, LOR, MPLKIP, NIPAL4, PEX7, PHYH, PNPLA1, POMP, SLC27A4, SNAP29, SPINK5, ST14, STS, SUMF1, TGM1, TGM5, VPS33B	15 BAP1, BRCA2, CDK4, CDKN2A, CHEK2, MC1R, MITF, MUTYH, POT1, PTEN, RB1, SLC45A2, TERT, TP53, TYR
Invitae	46* AAGAB, AQP5, ATP2C1, CAST, CD151, CDSN, COL17A1, COL7A1, CTSC, DSG1, DSP, DST, ENPP1, EXPH5, FERMT1, GJB6, ITGA3, ITGA6, ITGB4, JUP, KANK2, KLHL24, KRT1, KRT10, KRT14, KRT16, KRT17, KRT5, KRT6A, KRT6B, KRT6C, KRT9, LAMA3, LAMB3, LAMC2, LOR, PKP1, PLEC, POMP, RHBDF2, RSPO1, SERPINB7, SERPINB8, SLURP1, TAT, TRPV3	46 ABCA12, ABHD5, ALDH3A2, ALOX12B, ALOXE3, AP1S1, AQP5, CAST, CDSN, CERS3, CLDN1, CYP4F22, EBP, ELOVL1, ELOVL4, GJA1, GJB2, GJB3, GJB4, GJB6, KDSR, KRT1, KRT10, KRT2, KRT9, LIPN, LOR, MBTPS2, NIPAL4, PEX7, PHYH, PNPLA1, POMP, SDR9C7, SERPINB7, SERPINB8, SLC27A4, SNAP29, SPINK5, ST14, STS, SULT2B1, SUMF1, TGM1, VPS33B, ZMPSTE24	9 BAP1, BRCA2, CDK4, CDKN2A, MITF, POT1, PTEN, RB1, TP53
Blueprint	26 ATP2C1, CDSN, COL17A1, COL7A1, CSTA, DSG1, DSG2, DSG4, DSP, DST, EXPH5, FERMT1, GRIP1, ITGA3, ITGA6, ITGB4, KLHL24, KRT1, KRT14, KRT5, LAMA3, LAMB3, LAMC2, PKP1, PLEC, TGM5	39 ABCA12, ABHD5, ALDH3A2, ALOX12B, ALOXE3, CASP14, CDSN, CERS3, CSTA, CYP4F22, EBP, ERCC2, FLG, GJA1, GJB2, GJB3, GJB4, KDSR, KRT1, KRT10, KRT2, KRT9, LIPN, LOR, MBTPS2, MPLKIP, NIPAL4, OSMR, PEX7, PHYH, PNPLA1, SDR9C7, SLC27A4, SPINK5, ST14, STS, SUMF1, TGM1, TGM5	19 BAP1, BRCA1, BRCA2, CDK4, CDKN2A, DDB2, ERCC2, ERCC3, ERCC4, ERCC5, MITF, POT1, PTCH1, PTEN, SUFU, TP53, WRN, XPA, XPC
Prevention Genetics	18 COL17A1, COL7A1, DSP, DST, FERMT1, ITGA3, ITGA6, ITGB4, JUP, KRT10, KRT14, KRT5, LAMA3, LAMB3, LAMC2, PKP1, PLEC, TGM5	19 ABCA12, ABHD5, ALOX12B, ALOXE3, AP1S1, CERS3, CLDN1, CYP4F22, KRT1, KRT10, KRT2, KRT9, LIPN, NIPAL4, PNPLA1, POMP, SLC27A4, ST14, TGM1	10 BAP1, BRCA2, CDK4, CDKN2A, CHEK2, MITF, POT1, PTEN, RB1, TP53
CTGT	24 CAST, CDSN, CHST8, COL17A1, COL7A1, CSTA, DSP, DST, EXPH5, FERMT1, ITGA3, ITGA6, ITGB4, JUP, KLHL24, KRT14, KRT5, LAMA3, LAMB3, LAMC2, PKP1, PLEC, SERPINB8, TGM5	32 ABCA12, ALOX12B, ALOXE3, CASP14, CAST, CDSN, CERS3, CHST8, CSTA, CYP4F22, FLG, FLG2, GJA1, GJB3, GJB4, KDSR, KRT1, KRT10, KRT2, KRT83, LIPN, LOR, MBTPS2, NIPAL4, PNPLA1, POMP, SERPINB8, ST14, STS, SULT2B1, TGM1, TGM5

*Combined with palmoplantar keratoderma. Numbers show size of gene panel.