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. 2023 Sep 29;13:1253238. doi: 10.3389/fonc.2023.1253238

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Copyright © 2023 Zhao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTP1B dephosphorylates and promotes the degradation of PITX1 via the proteasome pathway. As upstream of PITX1, PTP1B is directly involved in inhibiting the expression of PITX1, as shown in the magnification of the dashed circle area, PTP1B can dephosphorylate the 160, 175 and 179 sites of PITX1, making PITX1 unstable and degraded through the proteasome pathway, so that PITX1 cannot promote RASAL1-induced RAS inactivation and initiation of the p53 signaling pathway. Therefore, overexpression of PTP1B can inhibit PITX1-mediated cell cycle arrest and promote tumor cell survival.