Figure 4.

PITX1 regulates noncoding RNAs. PITX1, as the upstream of STAT3, can directly inhibit the transcriptional activity of STAT3, and then inhibit LINC00662-mediated EMT and metastasis in tumor cells. LINC00662 can be encapsulated by exosomes and then secreted extracellularly to be captured by macrophages, LINC00662 can promote the transformation of macrophages into tumor-associated macrophages (TAM), and promote the transcription and translation of inflammatory factor CCL22 in macrophages, macrophages secrete CCL22 outside the cell to be received by tumor cells, thereby promoting the proliferation and metastasis of tumor cells, and overexpression of PITX1 can inhibit this process. In the upper left corner of the image are other noncoding RNAs that can be involved in regulating PITX1.