TABLE 1.
Characteristics of the articles included in the meta-analysis.
| Research article | Subject characteristic | Gender (F/M) | Injury model | Exercise protocol | Results |
|---|---|---|---|---|---|
| Zhao et al. (2022, China) | Mouse (C57BL/6, 8–10 wk old, n = 12) | M | MI/R | 4-wks swimming (90 min*2/day) | Left ventricular ejection fraction |
| Myocardial infarction volume | |||||
| Myocardial apoptosis | |||||
| Lou et al. (2021, China) | Mouse (C57BL/6, n = 12) | M | / | 9-days incremental cycling treadmill training (18 m/min, 1 h/day) | Microvessel density |
| Angiogenesis | |||||
| Wang et al. (2020, China) | Mouse (C57BL/6, 10 wk old, n = 11) | M | MCAO, IS, H/R | 4-wks treadmill exercise (10 m/min, 1 h/day, 5days/wk) | Myocardial infarction volume |
| Myocardial apoptosis | |||||
| Microvessel density | |||||
| Kränkel et al. (2020, Germany) | Human (n = 12) | M | CCS | 4-wks HIIT | Myocardial apoptosis |
| Nie et al. (2019, United States) | Mouse (C57BL/6J, 8–10 wk old) | M | C2C12 | / | Myocardial apoptosis |
| Angiogenesis | |||||
| Hou et al. (2019, China) | 1. Rats (Sprague‒Dawley, 6 wk old, n = 8) | M | MI/R, H/R | 1. 4-wks swimming (90 min*2/day, 7-days/wk) | Myocardial apoptosis |
| 2. Human (n = 32) | 2. 1-year rowing | Left ventricular ejection fraction | |||
| Myocardial infarction volume | |||||
| Bei et al. (2017, China) | 1. Human (n = 16) | M | I/R | 1. Bruce stress test (running) | Myocardial infarction volume |
| 2. Mouse (C57BL/6, 8 wk old, n = 4) | 2. 3-wks swimming (90 min*2/day) | Myocardial apoptosis | |||
| MA et al. (2018, China) | Mouse (C57BL/6, 8–10 wk old, n = 12–18) | M | HG/H | 4-wks treadmill running (5–10 m/min, 60 min/day, 5-days/wk) | Myocardial apoptosis |
| Angiogenesis | |||||
| Wilhelm et al. (2016, United Kingdom) | Human (n = 9) | M | / | incremental running | Angiogenesis |
| Chaturvedi et al. (2015, United States) | Mouse (db/db) | M | T2DM | 8-wks treadmill running (7–10 m/min, 300 m/day, 5-days/wk) | Fibrosis |
| Myocyte uncoupling |
wk, week; F/M, Female/male; MI/R, Myocardial ischemia/reperfusion injury; MCAO, middle cerebral artery occlusion; IS, MCAO-induced ischemic stroke; H/R, Hypoxia/reoxygenation injury; CCS, chronic coronary syndrome; I/R, Ischemia–reperfusion injury; HG/H, High glucose/hypoxia; T2DM, Type 2 diabetes; HIIT, High-intensity interval exercise training.