Table 2.
Comparison of lower limit of quantitation (LLOQ) values (nM) of selected gut microbial AAA metabolites analyzed in more than two studies. Abbreviations: IT, Ion-trap; TOF, Time-of-flight; Q, quadrupole; SQ, single quadrupole; TRAP, orbitrap; QTRAP, quadrupole and orbitrap.
| GC-MS (IT) [30] |
GC-MS (TOF) [26] |
GC-MS (SQ) [27] |
GC-MS (TOF) [31] |
GC-MS (SQ) [9] |
LC-MS/MS (TQ) [47] |
LC-MS/MS (TQ) [11] |
LC-MS/MS (Q-TRAP) [51] |
LC-MS/MS (TQ) [58] |
LC-MS/MS (TQ) [59] |
LC-MS/MS (TQ) [48] |
LC-MS (TRAP) [30] |
LC-MS/MS (TQ) [46] |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Standard solution matrix | Urine | Solvent | Serum | Feces | Solvent, cerebrospinal fluid, serum | Plasma | Solvent | Solvent | Solvent | Solvent | Solvent | Urine | Solvent |
| Hippuric acid | 58,036 | 12,837 | 125 | 2260 | 140 | ||||||||
| p-hydroxybenzoic acid | 2919 | 3620 | 500 | 14 | 182 | 38 | |||||||
| p-hydroxyphenylacetic acid | 5980 | 3286 | 500 | 1250 | 284 | 205 | 1324 | 25 | |||||
| Indole-3-acetic acid | 65,074 | 625 | 400 | 56 | 123 | 1 | 22 | 10 | |||||
| Indole-3-propionic acid | 119,970 | 438 | 400 | 3 | 285 | 41 | |||||||
| Phenylacetic acid | 19,833 | 3672 | 397 | 57 | 5924 | ||||||||
| Phenylpropionic acid | 9987 | 500 | 719 | 416 | 1006 | ||||||||
| 5-hydroxyindole acetic acid | 20 | 11 | 10 | ||||||||||
| Indoxyl sulfate | 366 | 8 | 240 |