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. 2023 Jul 20;83(20):3442–3461. doi: 10.1158/0008-5472.CAN-22-1337

Figure 6.

Figure 6. Prevention of radiation-induced NI by targeting apoptosis. A–C, A/E was assessed using open field test of Bax+/+ versus Bax−/− mice irradiated at P3-P6 and tested at 30 (A), 90 (B), or 180 (C) days. D, LD chamber test performed at indicated number of days after xRT. E, Mot was assessed using the rotarod test performed at indicated number of days after xRT. F, L/M was assessed using NORT performed at indicated number of days after xRT. G, L/M was assessed using the object-location memory test performed at 180 days after xRT. H, L/M was assessed using the Barnes maze test performed at 180 days after xRT. I and J, Despair and depression-like behavior was assessed using tail suspension (I) and FSTs (J) performed to assess despair and depression in animals at indicated number of days after xRT. K–M, Neurobehavioral composite scoring indicates the significance of differences in neurobehavioral impairments in animals irradiated at P3-P6 and tested at indicated period after xRT. Unless otherwise specified, comparison between groups was conducted by one-way or two-way ANOVA followed by Holm-Sidak post hoc multiple comparisons test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, nonsignificant.

Prevention of radiation-induced NI by targeting apoptosis. A–C, A/E was assessed using open field test of Bax+/+ versus Bax−/− mice irradiated at P3-P6 and tested at 30 (A), 90 (B), or 180 (C) days. D, LD chamber test performed at indicated number of days after xRT. E, Mot was assessed using the rotarod test performed at indicated number of days after xRT. F, L/M was assessed using NORT performed at indicated number of days after xRT. G, L/M was assessed using the object-location memory test performed at 180 days after xRT. H, L/M was assessed using the Barnes maze test performed at 180 days after xRT. I and J, Despair and depression-like behavior was assessed using tail suspension (I) and FSTs (J) performed to assess despair and depression in animals at indicated number of days after xRT. K–M, Neurobehavioral composite scoring indicates the significance of differences in neurobehavioral impairments in animals irradiated at P3-P6 and tested at indicated period after xRT. Unless otherwise specified, comparison between groups was conducted by one-way or two-way ANOVA followed by Holm-Sidak post hoc multiple comparisons test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, nonsignificant.