Fig. 2.

Tracheostomy-free/life survival from diagnosis of incident ALS cases based on TUDCA treatment. Kaplan–Meier survival plot displaying tracheostomy-free survival of patients with ALS in ERRALS study divided by controls (i.e., non-TUDCA-exposed patients, blue line), low-dose TUDCA-exposed patients (i.e., <1000 mg/daily dosage, red line), and high-dose TUDCA patients (≥1000 mg/daily dosage, green line). Survival was calculated by considering the time in months from symptom onset to death or tracheostomy (whichever occurred first) or the censoring date (the last day of follow-up, February 1st, 2022). The number of patients included in the analysis is presented every 20 months, with the number of censored patients between brackets. TUDCA: tauroursodeoxycholic acid.