Fig. 2.

Diagram of the critical-size bone defect in rat calvaria and histomorphometric analyses. (A) The amount of newly formed bone was calculated based on the defect width and the bone fill measurements in the peripheral area (1.25 mm × 0.8 mm) of both the sides (1.25 mm × 0.8 mm × 2) and the central area (2.5 mm × 0.8 mm). (B) The level of newly formed bone was calculated based on the defect width and the bone fill measurements on the top side (periosteum side, 5.0 mm × 0.4 mm) and the bottom side (dura mater side, 5.0 mm × 0.4 mm).