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. 2023 Oct 5;97:104821. doi: 10.1016/j.ebiom.2023.104821

Table 2.

Diabetes and probiotic clinical trials.

Trial identifier Trail phase (status) Title Conditions Interventions
Diabetes Mellitus type 2
NCT01765517 Completed Study to Explore the Effects of Probiotics on Endotoxin Levels in Type 2 Diabetes Mellitus Patients Diabetes Mellitus Type 2
  • -

    Dietary Supplement: Probiotics

  • -

    Dietary Supplement: Placebo
NCT02728414 Unknown Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Type 2 Diabetes Diabetes Mellitus, Type 2
  • -

    Dietary Supplement: Probiotics

  • -

    Dietary Supplement: Placebo
NCT03377946 Unknown Effect of Probiotics on Pre-diabetes and Diabetes in China Diabetes Mellitus, Type 2
  • -

    Biological: probiotics

  • -

    Biological: placebo
NCT04089280 Completed Probiotics in Metformin Intolerant Patients With Type 2 Diabetes
  • -

    Diabetes Mellitus, Type 2

  • -

    Metformin Adverse Reaction
  • -

    Dietary Supplement: Sanprobi Barrier-multispecies probiotic

  • -

    Other: Placebo Comparator
NCT05418179 Recruiting Effect of Probiotic Supplementation on Fecal Microbiota, Nutritional Status, Metabolic and Inflammatory Parameters in Patients With Type 2 Diabetes Mellitus Type 2 Diabetes Mellitus
  • -

    Dietary Supplement: Probiotic

  • -

    Dietary Supplement: Placebo
NCT04988594 Completed Effects of Yogurt With Probiotics in Adults With Type 2 Diabetes Mellitus Type 2 Diabetes
  • -

    Dietary Supplement: Lactobacillus acidophilus 207, Bifidobacterium lactis B420/205

  • -

    Dietary Supplement: Lactobacillus bulgaricus and Streptococcus thermophillus

  • -

    Dietary Supplement: No culture
NCT05066152 Completed The Effect of Single Probiotic on Metabolic Control in Type 2 Diabetes Type 2 Diabetes
  • -

    Dietary Supplement: Lactobacillus rhamnosus GG (ATCC 53103)

  • -

    Dietary Supplement: Placebo
NCT03434860 Completed Effect of Probiotic on Insulin Resistance in Type 2 Diabetes Patients
  • -

    Type 2 Diabetes

  • -

    Insulin Resistance
  • -

    Dietary Supplement: probiotic

  • -

    Dietary Supplement: placebo
NCT04191525 Completed Phase II Clinical Trial to Evaluate the Efficacy and Safety of the Treatment With BPL-1 in Adult Patients With Type 2 Diabetes Mellitus Type 2 Diabetes
  • -

    Dietary Supplement: BPL-1 Probiotic capsules

  • -

    Dietary Supplement: Placebo
NCT01250106 Unknown Probiotics as a Novel Approach to Modulate Gut Hormone Secretion and Risk Factors of Type 2 Diabetes and Complications
  • -

    Obesity

  • -

    Type 2 Diabetes

 Dietary Supplement: Lactobacillus reuteri
NCT03239366 Unknown A Study to Evaluate the Effect of BioK+ 50B® on Glycemic Control in a Type 2 Diabetes Population Type 2 Diabetes
  • -

    Other: BioK+ 100% probiotic

  • -

    Other: Placebo
NCT00413348 Unknown Type 2 Diabetes and the Effect of Probiotics
  • -

    Type 2 Diabetes

  • -

    Healthy

  • -

    Endotoxemia
  • -

    Drug: Lactobacillus acidophilus NCFM
NCT01620125 Completed Metabolic Control Before and After Supplementation With Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes Patients
  • -

    Type 2 Diabetes

  • -

    Insulin Resistance

 Dietary Supplement: Lactobacillus reuteri DSM 17938
NCT01752803 Unknown RCT Examining Effects of Probiotics in T2DM Individuals
  • -

    Type 2 Diabetes Mellitus

  • -

    Obesity

  • -

    Hypertension

  • -

    Hyperlipidemia
  • -

    Dietary Supplement: Probiotic

  • -

    Dietary Supplement: Placebo
NCT00699426 Completed The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes Type 2 Diabetes
  • -

    Drug: nexium

  • -

    Dietary Supplement: Yoghurt

  • -

    Drug: placebo + placebo
NCT02274272 Completed Effects of Genmont Probiotic on Improve the Level of Blood Glucose and Other Diabetic Associate Parameter in Type 2 Diabetes Patients Type 2 Diabetes
  • -

    Other: ADR-1

  • -

    Other: GMNL-263

  • -

    Other: placebo
NCT04296825 Completed Effect of Camel Milk With Probiotic on Type 2 Diabetes Mellitus Type 2 Diabetes
  • -

    Dietary Supplement: Camel milk containing Bifidobacterium animalis A6

  • -

    Dietary Supplement: Camel milk

  • -

    Dietary Supplement: Bifidobacterium animalis A6

  • -

    Dietary Supplement: Cow milk
NCT04201938 Completed Effect of Probiotic Co-administration With Omega-3 Fatty Acids on Obesity Parameters and Insulin Resistance
  • -

    Obesity

  • -

    Insulin Resistance

  • -

    Insulin Sensitivity

  • -

    Type 2 Diabetes

  • -

    Visceral Obesity
  • -

    Combination Product: Symbiter-Omega

  • -

    Dietary Supplement: Placebo
NCT05076656 Completed Epigenetic and Microbiota Modifications
  • -

    Diabetes type 2

  • -

    Obesity
  • -

    Dietary Supplement: Lactobacillus fermentum D3

  • -

    Biological: Fecal microbiota transplantation (FMT)

  • -

    Drug: Placebo
NCT02469558 Completed Probiotics in Diabesity: A Pilot Study
  • -

    Diabetes

  • -

    Obesity
  • -

    Dietary Supplement: Winclove 851 and 110

  • -

    Dietary Supplement: Placebo
NCT02144948 Completed Investigation of the Effect of E.-Coli-Nissle as Supporting Therapy to Standard Care of Diabetes Mellitus Type II Diabetes type 2 Drug: e.-coli-nissle
NCT01836796 Completed Metabolic Effects of Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes Diabetes type 2
  • -

    Dietary Supplement: Lactobacillus Reuteri

  • -

    Dietary Supplement: Lactobacillus Reuteri DSM17938
NCT00068094 Terminated The Effect of Good Bacteria on Nonalcoholic Fatty Liver Disease in Diabetics
  • -

    Fatty Liver

  • -

    Hepatic Steatosis

  • -

    Diabetes Mellitus

  • -

    Liver Diseases

 Drug: Probiotic-containing powde
NCT03037918 Completed Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans
  • -

    Insulin Sensitivity

  • -

    Insulin Resistance

  • -

    Type 2 Diabetes Mellitus

 Dietary Supplement: Yakult light
NCT01235026 Unknown Synbiotics and Low Grade Inflammation in Obese Subjects
  • -

    Obesity

  • -

    Diabetes Mellitus Type-2

  • -

    Insulin Resistance

  • -

    Metabolic Syndrome
  • -

    Dietary Supplement: Synbiotic

  • -

    Dietary Supplement: Placebo
NCT00655798 Completed Effect of Nutritional Interventions on Inflammatory Status in Healthy Overweight Men
  • -

    Overweight

  • -

    Diabetes

  • -

    Cardiovascular Disease
  • -

    Dietary Supplement: Placebo

  • -

    Dietary Supplement: Plain Yogurt + mix of anti-oxidants capsules

  • -

    Dietary Supplement: Yogurt containing Lactobacillus helveticus

  • -

    Dietary Supplement: Yogurt containing Bifidobacterium animalis ssp.
NCT04767789 Active, not recruiting Clinical Trial to Evaluate the Efficacy and Safety of the Probiotic Strains Limosilactocillus Reuteri DSM 32910 and Lacticaseibacillus Paracasei DSM 32851 on Glucose Homeostatis in Prediabetic Adults
  • -

    Prediabetic State

  • -

    Dysglycemia
  • -

    Dietary Supplement: NZ-GHMH-01

  • -

    Dietary Supplement: Placebo
NCT04341571 Active, not recruiting Effect of Probiotics vs Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
  • -

    PreDiabetes

  • -

    Impaired Glucose Tolerance

  • -

    Hyperglycemia

  • -

    Resistance, Insulin
  • -

    Dietary Supplement: Probiotics

  • -

    Drug: Metformin
NCT04428606 Completed Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes PreDiabetes
  • -

    Dietary Supplement: Metabolic Rheostat

  • -

    Dietary Supplement: Butyrate Ultra

  • -

    Dietary Supplement: Placebo
NCT04863313 Recruiting Effect of a Probiotic on the Glycemic Profile and the Fecal Microbiota of Prediabetic Subjects (PREDIABETCARE)
  • -

    PreDiabetes

  • -

    Overweight and Obesity
  • -

    Dietary Supplement: Probiotic

  • -

    Dietary Supplement: Placebo
Diabetes Mellitus type 1
NCT04579341 Recruiting Probiotics Supplementation Effect on Glucose Homeostasis in Children With Type 1 Diabetes Diabetes Mellitus, Type 1 Dietary Supplement: Probiotics
NCT03880760 Completed The Effect of Probiotics on Type 1 Diabetes Mellitus in Children Diabetes Mellitus, Type 1
  • -

    Other: L. johnsonii MH-68, B. animalis subsp. lactis CP-9 and L. salivarius AP-32

  • -

    Other: Placebo
NCT03032354 Unknown Probiotics in Newly Recognized Type 1 Diabetes Diabetes Mellitus, Type 1
  • -

    Drug: Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12

  • -

    Other: Placebo, (Placebo group)
NCT03423589 Completed Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics Diabetes Mellitus, Type 1 Dietary Supplement: VSL#3
NCT03556631 Completed Effect of Live Combined Bifidobacterium and Lactobacillus on Glycemic Control and Other Outcomes in Type 1 Diabetes Diabetes Mellitus, Type 1 Drug: live combined Bifidobacterium and Lactobacillus Tablets
NCT04141761 Active, not recruiting Probiotics in Newly Diagnosed T1D Type 1 Diabetes Mellitus
  • -

    Dietary Supplement: Visbiome

  • -

    Other: Placebo
NCT03961347 Recruiting Lactobacillus Johnsonii Supplementation in Adults With T1D Type 1 Diabetes Mellitus
  • -

    Drug: L. johnsonii Probiotic

  • -

    Drug: Placebo Capsule
NCT04335656 Recruiting Reducing Innate Inflammation in New Onset Type 1 Diabetes Type 1 Diabetes Mellitus
  • -

    Dietary Supplement: Lactiplantibacillus plantarum

  • -

    Other: Placebo
NCT03961854 Recruiting Lactobacillus Johnsonii in Children and Adolescents With T1D Type 1 Diabetes Mellitus
  • -

    Drug: L. johnsonii Probiotic

  • -

    Drug: Placebo Capsule
NCT04769037 Recruiting Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity Type 1 Diabetes Mellitus
  • -

    Dietary Supplement: B. infantis

  • -

    Dietary Supplement: Placebo