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In LPS-activated macrophages the induction of the iNOS gene results in a burst of nitric oxide (NO) production. NO has a pleiotropic effect inside the cell which results in the inhibition of the electron transport chain (OXPHOS), the E2 and E3 subunit of the pyruvate dehydrogenase (PDH), and few enzymes of the TCA cycle (ACO2, IDH, OGDH).
