Table 1.

Location, tissue distribution and substrates of MMP1 gene.

Name	Chromosomal location	MW pro/active	Distribution	Collagen substrates	Noncollagen substrates	Other targets and substrates
MMP1	11q22.3	55/45 KDa	Endothelium, intima, fibroblasts, SMCs, vascular adventitia, platelets, varicose veins	I, II, III, IV, VII, VIII, X, and gelatin	Aggrecan, perlecan, versican, proteoglycan link protein, serpins, nidogen, tenascin	Casein, antichymotrypsin, IL1β, pro‐TNFα, SDF1, antitrypsin, proteinase inhibitor, IGF‐BP3 and 5

Abbreviations: IL, interleukin; MMP, matrix metalloproteinase; SMC, smooth muscle cell; TNF, tumor necrosis factor.