Figure 5.

CRP levels in patients receiving MAS825 + SoC versus placebo during the treatment period (PD analysis set). Data presented as estimated geometric mean ratio to baseline in CRP ± SE. Log-transformed CRP data is modeled using MMRM model with treatment, visit, stratification factors, visit * treatment and visit * stratification factors as fixed effects and log-transformed baseline score and visit * log-transformed baseline score as a continuous covariate. Stratification factors = age group, administration of any anti-viral therapy, presence of comorbidities. Results were back transformed to obtain adjusted geo-mean, geo-mean ratio, and 90% CI. CRP: C-reactive protein; i.v.: intravenous; MMRM: mixed-effect repeated measures; SoC: standard of care.