TABLE 1.
Mutations in the QRDRs of gyrA and grlA genes accompanying sequential four-step mutations
| Mutation (gene) | Strain
|
Reference | |||
|---|---|---|---|---|---|
| MS5935 | MS5952 | MR5867 | MR6009 | ||
| First step (grlA) | Ser-80(TCC)→Phe(TTC) | Ser-80(TCC)→Tyr(TAC) | Glu-84(GAA)→Lys(AAA) | Ser-80(TCC)→Tyr(TAC) | 6 |
| Second step (gyrA) | Ser-84(TCA)→Leu(TTA) | Ser-84(TCA)→Leu(TTA) | Ser-84(TCA)→Leu(TTA) | Glu-88(GAA)→Lys(AAA) | 10 |
| Third step (grlA) | Glu-84(GAA)→Lys(AAA) | Ala-116(GCA)→Val(GTA) | Ser-80(TCC)→Phe(TTC) | Glu-84(GAA)→Lys(AAA) | This study |
| Fourth step (gyrA) | Glu-88(GAA)→Val(GTA) | —a | Glu-88(GAA)→Lys(AAA) | Ser-84(TCA)→Leu(TTA) | This study |
a
—, the fourth-step mutant of MS5952 was not obtained from the third-step mutant.