Table 2.
Proportions of donor-reactive cytokine producing CD137++ CD4 and CD8+ T cells for recipients receiving living and deceased donor kidneys
Living donor | Deceased donor | |||||
---|---|---|---|---|---|---|
CD137++ population of cyt pc * |
Rejector (N = 30) | Non-rejector (N = 40) |
P value | Rejector (N = 18) | Non-rejector (N = 11) | P value |
CD4+ polyfunctional (%) | 0.006 | 0.004 | 0.015 | 0.004 | 0.004 | 0.669 |
CD4+ triple+ (%) | 0.001 | 0.000 | 0.003 | 0.001 | 0.001 | 0.573 |
CD4+ double+ (%) | 0.005 | 0.003 | 0.028 | 0.004 | 0.003 | 0.544 |
CD4+ single+ (%) | 0.008 | 0.004 | 0.001 | 0.010 | 0.005 | 0.719 |
CD8+ polyfunctional (%) | 0.007 | 0.002 | 0.024 | 0.011 | 0.012 | 0.753 |
CD8+ triple+ (%)** | ||||||
CD8+ double+ (%) | 0.006 | 0.002 | 0.025 | 0.010 | 0.012 | 0.753 |
CD8+ single+ (%) | 0.022 | 0.010 | 0.017 | 0.026 | 0.021 | 0.787 |
*cyt pc, cytokine producing cells; % are of CD4+ and CD8+ T cells, respectively.
**CD8+ triple cytokine-producing cells were hardly detected and not included in this table.
Median values are depicted and values for R and NR are compared using the Mann–Whitney U test, P < 0.05 is considered statistically significant.