Table 1. Representative Polymerization Data.
| polymera | [M]/[I]b | initiator | Mn | D̵g |
|---|---|---|---|---|
| Azp16 | 25 | benzyl aminec | 2210g | N.D. |
| Azp21 | 50 | benzyl aminec | 2901g | N.D. |
| Azp18 | 100 | benzyl aminec | 2847g | N.D. |
| BnGlu73d | 25 | Co initiator | 15,710 | 1.19 |
| Azp11f | 10 | BnGlu73d | 1529g,i | N.D. |
| Azp24f | 25 | BnGlu73d | 3267g,i | N.D. |
| Azp114f | 100 | BnGlu73d | 15,790g,i | N.D. |
| Azp190f | 200 | BnGlu73d | 26,202g,i | N.D. |
| Azp15-s-AcOPro45 | 50 | Ni initiatore | 9467h | 1.30h |
| GalTzp35j | 31,030h | 1.02h | ||
| GalTzp15-s-AcOPro45j | 20,030h | 1.20h | ||
| GalTzp15-s-AcOPro45j | 37,540h | 1.07h |
a
Sample name and observed polypeptide DP.
b
Molar ratio of NCA to initiator.
c
Polymerization performed in 5% water in DMSO.
d
Polymerization performed in THF.
e
Polymerization performed in DMF.
f
Samples were analyzed as block polymers BnGlu73-b-Azpx for improved solubility.
g
Mn or D̵ as determined by 1H NMR in DMSO.
h
Mn or D̵ as determined by SEC/MALS/RI; D̵ could not be determined (N.D.) in cases where the polypeptide was poorly soluble in DMF.
i
Mn reported is for the PAzp segments only and does not include the macroinitiator.
j
SEC/MALS/RI analysis was performed after click-conjugation.