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. 2023 Jul 16;3(5):383–393. doi: 10.1021/acspolymersau.3c00011

Table 2. Results of Copper-Catalyzed Click Reactions on Various Azp-Containing Polypeptides.

backbonea alkynea equivsb product graft %c
Azp35 Gal 5 GalTzp35 99+
Azp35 EG 5 EGTzp35 96
Azp15-s-Hyp45 Gal 2 GalTzp15-s-Hyp45 99+
Azp15-s-Hyp45 Gal 5 GalTzp15-s-Hyp45 99+
Azp15-s-Hyp45 Glc 5 GalTzp15-s-Hyp45 99+
Azp15-s-Hyp45 EG 5 EGTzp15-s-Hyp45 99+
Azp15-s-Hyp45 Glu70 5 (Tzp15-s-Hyp45)-g-Glu70 99+
a

For the click reaction, Hyp, Gal, and Glc were protected with acetate groups and Glu with benzyl groups. All protecting groups were removed post-click.

b

Equivalents of alkyne per azide.

c

Grafting efficiency as determined by the combination of relative azide vs amide integrations by ATR–FTIR, 1H NMR, and Mn SEC/MALS/RI.