Table 3.
Pleiotropy analysis
outcome | exposure | MR-Egger | MR-PRESSO | |||
---|---|---|---|---|---|---|
egger_intercept | P-value | Raw P-value | Outlier-corrected P-value | Global Test P-value | ||
PDW | ApoA1 | -0.0023889 | 0.07525349 | < 0.001 | < 0.001 | < 0.001 |
PDW | ApoB | 0.00182644 | 0.29193778 | 0.040 | 0.005 | < 0.002 |
PDW | HDL-C | 0.00078889 | 0.55968876 | < 0.001 | < 0.001 | < 0.003 |
PDW | triglycerides | -0.0017449 | 0.08720377 | < 0.001 | < 0.001 | < 0.004 |
MPV | LDL-C | -0.0001743 | 0.88624577 | 0.067 | 0.002 | < 0.005 |
PDW: Platelet distribution width, MPV: Mean platelet volume, ApoA1: apolipoprotein A-1, ApoB: apolipoprotein B, HDL-C: high-density-lipoprotein cholesterol, LDL-C: low-density-lipoprotein cholesterol