Table 5.
Univariable and multivariable analysis (Febrile neutropenia)
| Covariates | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-values | OR (95% CI) | P-values | |
| Age (≥ 65 years vs. < 65 years) | 2.941 (0.585–14.796) | 0.191 | ||
| Gender (female vs. male) | 0.400 (0.079–2.022) | 0.268 | ||
| BMI (< 20.0 kg/m2 vs. ≥ 20.0 kg/m2) | 0.400 (0.107–1.490) | 0.172 | ||
| Alb (< 3.5 g/dL vs. ≥ 3.5 g/dL) | 3.710 (0.741–18.580) | 0.111 | ||
| T-Bil (> 1.5 mg/dL vs. ≤ 1.5 mg/dL) | 26.500 (2.620–268.036) | 0.006 | 31.316 (2.052–477.843) | 0.013 |
| Ccr (< 50 mL/min vs. ≥ 50 mL/min) | 1.600 (0.281–9.109) | 0.596 | ||
|
Prior platinum-based doublet regimens (L-OHP containing vs. CDDP containing) |
11.000 (1.326–91.229) | 0.026 | 12.502 (1.141–137.022) | 0.039 |
| No. of prior chemotherapy cycles (≥ median vs. < median) | 2.375 (0.665–8.486) | 0.183 | ||
| History of surgery for primary lesion (No vs. Yes) | 0.464 (0.125–1.727) | 0.252 | ||
| Liver metastasis (Yes vs. No) | 1.577 (0.408–6.099) | 0.509 | ||
| ANC before wPTX + RAM (< median vs. ≥ median) | 0.663 (0.187–2.352) | 0.525 | ||
OR Odds ratio, CI Confidence interval, BMI Body mass index, Alb Serum albumin, T-Bil Total bilirubin, Ccr Creatinine clearance, L-OHP Oxaliplatin, ANCs Absolute neutrophil counts