Extended Data 10. Spatiotemporal dynamics of IT^PlxnD1 and PT^Fezf2 under ketamine anesthesia across mice.

a. Mean spectrogram of IT^PlxnD1 and PT^Fezf2 activity from MOp and RSp (18 sessions across 6 mice for each cell type).

b. Difference between IT^PlxnD1 and PT^Fezf2 average relative power maps for each frequency bands (18 sessions from 6 mice for each cell type). Only significantly different pixels are displayed (two-sided Wilcoxon rank sum test with p-value adjusted by FDR = 0.05). Blue pixels indicate values significantly larger in IT^PlxnD1 compared to PT^Fezf2 and vice versa for green pixels.

c. Distribution of IT^PlxnD1 (blue) and PT^Fezf2 (green) spatial power maps for each frequency band projected to the subspace spanned by the top two principal components (n = 18 maps in each group). IT^PlxnD1 and PT^Fezf2 both clustered independently with further segregation between IT^PlxnD1 0.6–0.9 Hz and 1–1.4 Hz frequency bands, substantiating the distinct activation patterns between the two populations.

d. Activation sequence of the most dominant pattern (1^st dimension) identified by seqNMF from IT^PlxnD1 (top) and PT^Fezf2 (bottom) activity combined across mice and sessions.