TABLE 2.
Mutations in the 23S rRNA gene and associated MLS phenotypes of clinical H. pylori isolates
| H. pylori straina | 23S rRNA gene mutation | MIC (μg/ml)b
|
MLS pheno- typec | ||||
|---|---|---|---|---|---|---|---|
| Cla | Cln | Qnp | Dfp | RP59500 | |||
| UA802 | Wild type | 0.004 | 32 | 4 | 8 | 2 | S |
| A | A2143G | 4 | 256 | 4 | 8 | 2 | R-II |
| B | A2143G | 1 | 256 | 4 | 8 | 0.5 | R-II |
| D | A2142G | 8 | >512 | 64 | 8 | 1 | R-I |
| MQ | A2142G | 16 | >512 | 128 | 8 | 1 | R-I |
| E | A2142G | 16 | >512 | 128 | 8 | 2 | R-I |
| Eryr-1 | A2142G | 16 | >512 | 128 | 8 | 2 | R-I |
| Clar-1 | A2142G | 16 | >512 | 128 | 8 | 2 | R-I |
a
Eryr-1 and Clar-1 are erythromycin- and clarithromycin-resistant strains of UA802, respectively, obtained by transformation of the erythromycin or clarithromycin resistance determinant from strain E (30).
b
Abbreviations for antibiotics: Cla, clarithromycin; Cln, clindamycin; Qnp, quinupristin (streptogramin B); Dfp, dalfopristin (streptogramin A); RP59500, mixture of quinupristin and dalfopristin.
c
S, susceptible; R-II, type II resistance; R-I, type I resistance.