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[Preprint]. 2023 Sep 26:rs.3.rs-3385749. [Version 1] doi: 10.21203/rs.3.rs-3385749/v1

Extended Data Figure 6 |. Safety of uPAR CAR T cells in aged mice.

Extended Data Figure 6 |

Mice received cell infusions at 18–20 months. a, Weight of mice 24h before and at different time points after cell infusion (n=12 mice for untransduced T cells [UT]; n=11 for h.19-m.28z; n=12 for m.uPAR-m.28z). b, Levels of triglycerides 20 days after cell infusion (n=12 mice for UT; n=11 for h.19-m.28z; n=13 for m.uPAR-m.28z). c, Levels of cholesterol 20 days after cell infusion (n=12 for UT and for h.19-m.28z; n=13 for m.uPAR-m.28z). d, Levels of ALT 20 days after cell infusion (sample sizes as in c). e, Levels of AST 20 days after cell infusion (n=12 for UT; n=11 for h.19-m.28z; n=13 for m.uPAR-m.28z). f, BUN/creatinine ratio 20 days after cell infusion (sample sizes as in c). g, Creatine kinase (CK) 20 days after cell infusion (n=12 for UT; n=9 for h.19-m.28z; n=11 for m.uPAR-m.28z). h, Levels of hemoglobin 20 days after cell infusion (n=11 for UT; n=11 for h.19-m.28z; n=10 for m.uPAR-m.28z). i, Number of platelets 20 days after cell infusion (n=11 for UT; n=11 for h.19-m.28z; n=10 for m.uPAR-m.28z). j, Number of lymphocytes 20 days after cell infusion (n=11 for UT; n=11 for h.19-m.28z; n=10 for m.uPAR-m.28z). k, Number of monocytes 20 days after cell infusion (n=11 for UT; n=11 for h.19-m.28z; n=10 for m.uPAR-m.28z). l, Number of neutrophils 20 days after cell infusion (n=11 for UT; n=10 for h.19-m.28z; n=10 for m.uPAR-m.28z). m, Number of eosinophils 20 days after cell infusion (n=11 for UT; n=11 for h.19-m.28z; n=10 for m.uPAR-m.28z). Results for all panels are from 2 independent experiments. Data are mean ± s.e.m.; p values from two-tailed unpaired Student’s t-test (b-m).