Extended Data Figure 4|. Upregulation of uPAR and senescence signatures in aged human pancreas.

Single-cell RNAsequencing data of human pancreas of different ages from²⁹ was analyzed. a, Uniform manifold approximation and projection (UMAP) visualization of Plaur expression across pancreas cell types in young humans (0–6 years old) and old humans (50–76 years old).b, UMAP visualization of senescence signature expression²¹ across pancreas cell types in young humans (0–6 years old) and old humans (50–76 years old). c, Quantification of the proportion of uPAR positive and negative cells by cell type and age. d, Quantification of the proportion of senescent signature expressing or non-expressing cells cells by cell type and age.